Pharmaceutical Research and Therapeutic Sciences

ABSTRACT

Emergency medicine, trauma care, and surgical practice face ongoing difficulties with their requirements for immediate wound treatment. Conventional wound dressings and hemostatic agents require multiple minutes to stop bleeding and create tissue seals, which leads to higher chances of infection and secondary issues. The research investigates the creation and testing process of an innovative biomaterial called BioGel, which achieves both wound closure and bleeding control within 15 seconds. BioGel exists as a biocompatible hydrogel that uses polymer-based materials to build its structure while incorporating chitosan, alginate, and bioactive nanoparticles, which enable fast clotting and tissue bonding .

The researchers conducted their study using both laboratory and animal testing methods to evaluate the gel's ability to stop bleeding, its effectiveness against germs, and its compatibility with body tissues. BioGel demonstrated a substantial decrease in bleeding duration when researchers compared it to standard gauze and commercial hemostatic products, according to statistical analysis, which showed significant differences at p < 0.05. The tissue study found that epithelial cells grew back to their original state while the body showed only a slight healing response. The material showed strong antimicrobial effects against typical infection-causing germs, which decreased the possibility of developing infections.

The statistical analysis demonstrated that results from various tests could be replicated and showed statistically significant outcomes. The fast-acting BioGel product works because it has two functions that produce an immediate physical blockade and start the blood clotting process.

This innovation holds significant promise for emergency care, battlefield medicine, and surgical applications, which require immediate control of active bleeding. The research requires additional clinical trials to establish its safety and performance for human testing.

Keywords: BioGel; Wound Healing; Rapid Hemostasis; Hydrogel; Chitosan; Tissue Regeneration; Emergency Medicine; Biomaterials